In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2017

In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris

Anuradha Chowdhary
Afsane Vaezi
  • Function : Author
Hamid Badali

Abstract

ABSTRACT We determined the in vitro interactions between echinocandins and azoles against 10 multidrug-resistant Candida auris strains by use of a microdilution checkerboard technique. Our results suggest synergistic interactions between micafungin and voriconazole with fractional inhibitory concentration index (FICI) values of 0.15 to 0.5, and we observed indifferent interactions when micafungin was combined with fluconazole (FICI, 0.62 to 1.5). Combinations of caspofungin with fluconazole or voriconazole exhibited indifferent interactions. No antagonism was observed for any combination.

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hal-03997759 , version 1 (20-02-2023)

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Hamed Fakhim, Anuradha Chowdhary, Anupam Prakash, Afsane Vaezi, Eric Dannaoui, et al.. In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris. Antimicrobial Agents and Chemotherapy, 2017, 61 (11), ⟨10.1128/AAC.01056-17⟩. ⟨hal-03997759⟩

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