Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Cancers Year : 2021

Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer

Abstract

The prognostic value of the CRP to albumin ratio (CAR) among older adults with cancer is not known. Six hundred and three older outpatients with cancer and undergoing geriatric assessment before therapeutic decisions were prospectively recruited from the PF-EC cohort study. Serum albumin levels, serum CRP levels and the CAR were prospectively recorded at baseline, and at each consultation thereafter, as follows: 1, 3, 6, 9, 12, 18, 24 and 36 months. Frailty was defined as a G8-index ≤ 14. The primary endpoint was longitudinal variation in the CAR during the study follow-up. Two clusters in the longitudinal trajectories of the CAR were identified, one favourable, with lower values and better overall survival (cluster A), and the second with higher values and less favourable overall survival (cluster B). The median CAR [95% CI] for clusters A and B were respectively: 0.17 [0.04–0.48] and 0.26 [0.04–0.79] at baseline (p = 0.01), and 0.18 [0.02–3.17] and 0.76 [0.03–6.87] during the study follow-up (p < 0.0001). Cluster B was associated with the frailest patients with metastatic disease, mainly driven by a high CRP level at baseline, and low albumin during the study follow-up. Our study results suggest that the most risk-prone patients have a cancer-cachexia trajectory.
Fichier principal
Vignette du fichier
cancers-13-05782.pdf (1.9 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-04148609 , version 1 (03-07-2023)

Identifiers

Cite

Fiamma Burgassi, Elena Paillaud, Johanne Poisson, Guilhem Bousquet, Frédéric Pamoukdjian. Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer. Cancers, 2021, 13 (22), pp.5782. ⟨10.3390/cancers13225782⟩. ⟨hal-04148609⟩
19 View
16 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More