A multi-scale model for CD8+ T cell immune response
Résumé
CD8+ T cells are important for immune responses against viruses and bacteria, as well as
for tumor surveillance. When the CD8+ T cell recognizes its antigen (i.e. it enters in contact
with an antigen presenting cell), it gets activated, it then differentiates into an effector, and
kills infected or malignant cells bearing the antigen. Meanwhile, part of activated CD8+ T
cells differentiate into memory cells. CD8+ T cell activation, differentiation, proliferation
and death are controlled by intracellular signaling based on cell interactions with their mi-
croenvironment and gene regulation (1), (2). Here we present a multiscale model for CD8+
T cell immune response.
Origine : Fichiers produits par l'(les) auteur(s)