Abstract The data of 17 air quality monitoring stations of Greater Cairo are used to perform a statistical analysis aiming to detect any heterogeneous surface effects of mineral dust on the distribution of reactive trace gases (SO 2 NO 2 , and ozone) in. After a thorough quality check, the methodology consisted of i) selecting representative stations by agglomerative hierarchical clustering, ii) identifying dust events based on PM 10 measurements, remote sensing observations, and meteorology, and iii) applying the non-parametric Kruskal Wallis (KW) hypothesis test to compare (at the 95% confidence level) trace gas concentrations during dust and non-dust events. The representative stations display either a background-like or a bimodal variability with concentrations (even that of the secondary product NO 2 ) peaking at traffic rush hours but during dust storms all stations capture the signal of mineral dust advection. Eight wintertime and springtime dust cases are retained for the study. After the role of the confounding factors (i.e., ventilation index, relative humidity, and photolysis) has been carefully discussed and taken into account, the KW test shows that there is no significant reduction of the SO 2 , NO 2 and ozone concentrations attributable to dust during 7 of the 8 events. The drop of the concentrations coinciding with the advection of dry dust-laden Saharan air masses is rather an effect of the dilution resulting from the combination of large wind speed and mixing layer height than of the heterogeneous uptake of these gases on the mineral dust surface.