Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research - Université Paris-Est-Créteil-Val-de-Marne
Journal Articles PLoS ONE Year : 2019

Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research

1 CEPOI - Centre d'Études Périnatales de l'Océan Indien
2 CHU La Réunion - Centre Hospitalier Universitaire de La Réunion
3 Centre Hospitalier Sud Francilien
4 Hôpital Necker - Enfants Malades [AP-HP]
5 CHRO - Centre Hospitalier Régional d'Orléans
6 CHIC - Centre Hospitalier Intercommunal de Créteil
7 Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
8 CHU Caen
9 Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras
10 Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion]
11 CHU de Poitiers [La Milétrie] - Centre hospitalier universitaire de Poitiers = Poitiers University Hospital
12 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]
13 Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy]
14 CHU Nîmes - Centre Hospitalier Universitaire de Nîmes
15 CHCB - Centre Hospitalier de la Côte Basque
16 GHUPSSD - Groupe Hospitalier Universitaire Paris Seine-Saint-Denis
17 Centre Hospitalier Métropole Savoie [Chambéry]
18 GHH - Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS)
19 CHI André Gregoire - Centre Hospitalier Intercommunal André Grégoire [Montreuil]
20 Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique]
21 Centre Hospitalier de Mayotte
22 CHU Pointe-à-Pitre / Abymes [Guadeloupe]
23 CHPC - CH Centre Hospitalier Public du Cotentin
24 CHT - Centre hospitalier territorial Gaston-Bourret [Dumbea]
25 GHEF - Grand Hôpital de l'Est Francilien
26 Centre Hospitalier de Lens
27 CH Saint-Brieuc Paimpol Tréguier - Centre hospitalier Saint-Brieuc Paimpol Tréguier
28 Centre Hospitalier René Dubos [Pontoise]
29 Centre hospitalier de Pau
30 Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française]
31 CHU Trousseau [APHP]
32 Hôpital Robert Debré
Ceneric Alexandre
  • Function : Author

Abstract

Objectives: The primary objective of this study is to determine the current level of patient medication exposure in Level 3 Neonatal Wards (L3NW). The secondary objective is to evaluate in the first month of life the rate of medication prescription not cited in the Summary of Product Characteristics (SmPC). A database containing all the medication prescriptions is collected as part of a prescription benchmarking program in the L3NW. Material and methods: The research is a two-year observational cohort study (2017-2018) with retrospective analysis of medications prescribed in 29 French L3NW. Seventeen L3NW are present since the beginning of the study and 12 have been progressively included. All neonatal units used the same computerized system of prescription, and all prescription data were completely de-identified within each hospital before being stored in a common data warehouse. Results: The study population includes 27,382 newborns. Two hundred and sixty-one different medications (International Nonproprietary Names, INN) were prescribed. Twelve INN (including paracetamol) were prescribed for at least 10% of patients, 55 for less than 10% but at least 1% and 194 to less than 1%. The lowest gestational ages (GA) were exposed to the greatest number of medications (18.0 below 28 weeks of gestation (WG) to 4.1 above 36 WG) (p<0.0001). In addition, 69.2% of the 351 different combinations of an medication INN and a route of administration have no indication for the first month of life according to the French SmPC. Ninety-five percent of premature infants with GA less than 32 weeks received at least one medication not cited in SmPC. Conclusion: Neonates remain therapeutic orphans. The consequences of polypharmacy in L3NW should be quickly assessed, especially in the most immature infants.
Fichier principal
Vignette du fichier
document.pdf (818.35 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

hal-04307319 , version 1 (29-05-2024)

Licence

Identifiers

Cite

Béatrice Gouyon, Séverine Martin-Mons, Silvia Iacobelli, Hasinirina Razafimahefa, Elsa Kermorvant-Duchemin, et al.. Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research. PLoS ONE, 2019, 14 (9), pp.e0222667. ⟨10.1371/journal.pone.0222667⟩. ⟨hal-04307319⟩
121 View
32 Download

Altmetric

Share

More