Clinical spectrum of ischaemic arterial diseases associated with COVID-19: a series of four illustrative cases - Université Paris-Est-Créteil-Val-de-Marne Accéder directement au contenu
Article Dans Une Revue European Heart Journal. Case Reports Année : 2021

Clinical spectrum of ischaemic arterial diseases associated with COVID-19: a series of four illustrative cases

Henri Guillet
Romain Gallet
  • Fonction : Auteur
Vincent Pham
  • Fonction : Auteur
Raphaelle Huguet
  • Fonction : Auteur
Pascal Lim
  • Fonction : Auteur
Marc Michel
  • Fonction : Auteur
Mehdi Khellaf

Résumé

Abstract Background Severe coronavirus-induced disease 2019 (COVID-19) leads to acute respiratory distress syndrome with an increased risk of venous thrombo-embolic events. To a much lesser extent, arterial thrombo-embolic events have also been reported in this setting. Case summary Here, we describe four different cases of COVID-19 infection with ischaemic arterial events, such as a myocardial infarction with high thrombus load, ischaemic stroke on spontaneous thrombosis of the aortic valve, floating thrombus with mesenteric, splenic and renal infarction, and acute limb ischaemia. Discussion Cardiovascular risk factors such as hypertension, obesity, and diabetes are comorbidities most frequently found in patients with a severe COVID-19 infection and are associated with a higher death rate. Our goal is to provide an overview of the clinical spectrum of ischaemic arterial events that may either reveal or complicate COVID-19. Several suspected pathophysiological mechanisms could explain the association between cardiovascular events and COVID-19 (role of systemic inflammatory response syndrome, endothelial dysfunction, activation of coagulation cascade leading to a hypercoagulability state, virus-induced secondary antiphospholipid syndrome). We need additional studies of larger size, to estimate the incidence of these arterial events and to assess the efficacy of anticoagulation therapy.

Dates et versions

hal-04391527 , version 1 (12-01-2024)

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Citer

Henri Guillet, Romain Gallet, Vincent Pham, Thomas D’humières, Raphaelle Huguet, et al.. Clinical spectrum of ischaemic arterial diseases associated with COVID-19: a series of four illustrative cases. European Heart Journal. Case Reports, 2021, 5 (1), pp.ccd.29795. ⟨10.1093/ehjcr/ytaa488⟩. ⟨hal-04391527⟩

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