Clinical spectrum of ischaemic arterial diseases associated with COVID-19: a series of four illustrative cases - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles European Heart Journal. Case Reports Year : 2021

Clinical spectrum of ischaemic arterial diseases associated with COVID-19: a series of four illustrative cases

Henri Guillet
Romain Gallet
  • Function : Author
Vincent Pham
  • Function : Author
Raphaelle Huguet
  • Function : Author
Pascal Lim
  • Function : Author
Marc Michel
  • Function : Author
Mehdi Khellaf

Abstract

Abstract Background Severe coronavirus-induced disease 2019 (COVID-19) leads to acute respiratory distress syndrome with an increased risk of venous thrombo-embolic events. To a much lesser extent, arterial thrombo-embolic events have also been reported in this setting. Case summary Here, we describe four different cases of COVID-19 infection with ischaemic arterial events, such as a myocardial infarction with high thrombus load, ischaemic stroke on spontaneous thrombosis of the aortic valve, floating thrombus with mesenteric, splenic and renal infarction, and acute limb ischaemia. Discussion Cardiovascular risk factors such as hypertension, obesity, and diabetes are comorbidities most frequently found in patients with a severe COVID-19 infection and are associated with a higher death rate. Our goal is to provide an overview of the clinical spectrum of ischaemic arterial events that may either reveal or complicate COVID-19. Several suspected pathophysiological mechanisms could explain the association between cardiovascular events and COVID-19 (role of systemic inflammatory response syndrome, endothelial dysfunction, activation of coagulation cascade leading to a hypercoagulability state, virus-induced secondary antiphospholipid syndrome). We need additional studies of larger size, to estimate the incidence of these arterial events and to assess the efficacy of anticoagulation therapy.

Dates and versions

hal-04391527 , version 1 (12-01-2024)

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Henri Guillet, Romain Gallet, Vincent Pham, Thomas D’humières, Raphaelle Huguet, et al.. Clinical spectrum of ischaemic arterial diseases associated with COVID-19: a series of four illustrative cases. European Heart Journal. Case Reports, 2021, 5 (1), pp.ccd.29795. ⟨10.1093/ehjcr/ytaa488⟩. ⟨hal-04391527⟩

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