Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles European Heart Journal: Acute Cardiovascular Care Year : 2020

Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage

Noreen Butt
  • Function : Author
Lk Bache-Mathiesen
  • Function : Author
A Ushakova
  • Function : Author
Je Nordrehaug
  • Function : Author
Se Jensen
  • Function : Author
Ps Munk
  • Function : Author
N Danchin
  • Function : Author
Hs Hansen
  • Function : Author
F Paganelli
  • Function : Author
P Le Corvoisier
  • Function : Author
H Firat
  • Function : Author
D Erlinge
  • Function : Author
D Atar
  • Function : Author
Ai Larsen
  • Function : Author

Abstract

Background The inflammatory marker long pentraxin 3 (PTX3) has been shown to be a strong predictor of 30-day and one-year mortality after acute myocardial infarction. The aim of this study was to evaluate the kinetic profile of PTX3 and its relationship with interleukin 6 (IL-6), high-sensitive C-reactive protein (hs-CRP) and infarct size. Methods PTX3, IL-6 and hs-CRP were measured at predefined time points, at baseline (before percutaneous coronary intervention (PCI)), at 12 and 72 hours after PCI in 161 patients with first-time ST elevation myocardial infarction (STEMI). Results PTX3 and IL-6 levels increased in the early phase, followed by a gradual decrease between 12 and 72 hours. There were statistically significant correlations between PTX3 and IL-6 in general, for all time points and for changes over time (0–72 hours). In a linear mixed model, PTX3 predicted IL-6 ( p < 0.001). PTX3 is also correlated with hs-CRP in general, and at each time point post PCI, except at baseline. PTX3, IL-6 and hs-CRP were all significantly correlated with infarct size in general, and at the peak time point for maximum troponin I. In addition, there was a modest correlation between IL-6 levels at baseline and infarct size at 72 hours after PCI ( ρ = 0.23, p = 0.006). Conclusions PTX3 had a similar kinetic profile to IL-6, with an early increase and decline, and was statistically significantly correlated with markers of infarct size in STEMI patients post primary PCI. Baseline levels of IL-6 only predicted infarct size at 72 hours post PCI.

Dates and versions

hal-04395618 , version 1 (15-01-2024)

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Noreen Butt, Lk Bache-Mathiesen, A Ushakova, Je Nordrehaug, Se Jensen, et al.. Pentraxin 3 in primary percutaneous coronary intervention for ST elevation myocardial infarction is associated with early irreversible myocardial damage. European Heart Journal: Acute Cardiovascular Care, 2020, 9 (4), pp.302-312. ⟨10.1177/2048872620923641⟩. ⟨hal-04395618⟩

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