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EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Adolescent Transcriptome ATP Binding Cassette Transporter Family Health PTPN22 gene Antigen Presentation Rare variants Autoimmune thyroid disease In silico simulations Computational modeling Ankylosing spondylitis Network inference Rheumatoid Arthritis France Humans Biologie computationnelle des systèmes ASSOCIATION STUDY Age of Onset Middle Aged Human genomics Rheumatoid Case-Control Studies Génétique Biological pathway HLA-DRB1 Cohort Studies Rheumatoid Factor Receptors Phenotype ABCB1 Logical modelling Computational biology Disease maps HLA-DR Antigens Epitopes Risk Factors Tunisia HLA-DRB1 Chains Alleles Single Nucleotide Europe Age Factors Environment Polyarthrite rhumatoïde Biocuration Genetic Linkage Genetic Ankylosing RHEUMATOID ARTHRITIS Algerian population Gene Frequency Young Adult Genetics Association study Rheumatoid Arthritis Patient Family Female Non-Receptor Type 22 Odds Ratio Autoantibodies Genetic Predisposition to Disease Metabolic reprogramming Adult Autoimmune thyroid diseases European Continental Ancestry Group Autoantibody Production Analysis Computational systems biology Genotype POLYMORPHISM Reproducibility APOPTOSIS Complex genetic disease Male Genetic Association Studies Arthritis Antibodies Autoimmunity Shared Epitope Hybrid modeling Animals Systems biology Rheumatoid arthritis Antigens Databases Protein Tyrosine Phosphatase Aged Binding Sites Annotation standards Autoimmune Diseases African Continental Ancestry Group Anti-citrullinated protein antibodies Haplotypes Linkage Disequilibrium Algeria Polymorphism Anti-Idiotypic Antirheumatic Agents Biologie des systèmes 80 and over

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