In vitro and in vivo evaluation of the genotoxic and antigenotoxic potential of the major Chios mastic water constituents - Université Paris-Est-Créteil-Val-de-Marne
Article Dans Une Revue Scientific Reports Année : 2018

In vitro and in vivo evaluation of the genotoxic and antigenotoxic potential of the major Chios mastic water constituents

Résumé

Chios mastic products are well-known for their broad applications in food industry, cosmetics, and healthcare since the antiquity. Given our recent finding that Chios mastic water (CMW) exerts antigenotoxic action, in the present study, we evaluated the genotoxic as well as the antigenotoxic potential of the four major compounds of CMW, namely, verbenone, α-terpineol, linalool, and transpinocarveol. The cytokinesis block micronucleus (CBMN) assay in cultured human lymphocytes and the Drosophila Somatic Mutation And Recombination Test (SMART), also known as the wing spot test, were employed. None of the four major CMW's constituents or their mixtures showed genotoxic or recombinogenic activity in either of the assays used. Co-treatment of each of the constituents with MMC revealed that all except trans-pinocarveol exerted antigenotoxic potential. Moreover, coadministration of verbenone with linalool or α-terpineol presented statistically significant reduction of MMC-induced mutagenicity. In conclusion, the major CMW constituents were shown to be free of genotoxic effects, while some exerted antigenotoxic activity either alone or in combinations, suggesting synergistic phenomena. Our results provide evidence on the key antigenotoxicity effectors of the plant extract CMW.
Fichier principal
Vignette du fichier
2018 Sci Rep; mastic water constituents.pdf (1.09 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03163397 , version 1 (09-03-2021)

Identifiants

Citer

Elena Drosopoulou, Dimitris Vlastos, Ioanna Efthimiou, Paraskevi Kyrizaki, Sofia Tsamadou, et al.. In vitro and in vivo evaluation of the genotoxic and antigenotoxic potential of the major Chios mastic water constituents. Scientific Reports, 2018, 8 (1), ⟨10.1038/s41598-018-29810-y⟩. ⟨hal-03163397⟩

Collections

INSERM IMRB UPEC
45 Consultations
68 Téléchargements

Altmetric

Partager

More