In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2018

In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp

Abstract

ABSTRACT In vitro combinations of isavuconazole with echinocandins were evaluated against 30 Aspergillus strains with a two-dimensional checkerboard microdilution method and an agar-based diffusion method. With the checkerboard method, the three combinations showed indifferent interactions for all strains. With the agar-based method, indifferent interactions were found for all strains for isavuconazole-micafungin and isavuconazole-anidulafungin. For the isavuconazole-caspofungin combination, indifference was found in 24/30 strains, synergism in 4/30 strains, and antagonism in 2/30 strains.

Dates and versions

hal-03997741 , version 1 (20-02-2023)

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A. Raffetin, V. Courbin, V. Jullien, E. Dannaoui. In Vitro Combination of Isavuconazole with Echinocandins against Azole-Susceptible and -Resistant Aspergillus spp. Antimicrobial Agents and Chemotherapy, 2018, 62 (1), ⟨10.1128/AAC.01382-17⟩. ⟨hal-03997741⟩

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