In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2017

In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species

Saeed Emami
  • Function : Author
Afsane Vaezi
  • Function : Author
Seyedeh Mahdieh Hashemi
  • Function : Author
Leila Faeli
  • Function : Author
Kambiz Diba
  • Function : Author
Hamid Badali

Abstract

ABSTRACT The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.

Dates and versions

hal-03997772 , version 1 (20-02-2023)

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Hamed Fakhim, Saeed Emami, Afsane Vaezi, Seyedeh Mahdieh Hashemi, Leila Faeli, et al.. In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species. Antimicrobial Agents and Chemotherapy, 2017, 61 (1), ⟨10.1128/AAC.01106-16⟩. ⟨hal-03997772⟩

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