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Journal Articles Tetrahedron Letters Year : 1997

Kinetic Resolution of Secondary Alcohols Mediated by Rabbit Gastric Lipase

Abstract

Secondary benzylic alcohols were kinetically resolved by rabbit gastric lipase-mediated acylation with isopropenyl acetate. Among all the substrates tested, a high enantioselectivity was observed only for 1-[2-(6-methoxy)naphthyl]ethanol 3a (E>500). Allylic alcohols 14a and 15a were also efficiently resolved (E = 26 and51 respectively).
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Dates and versions

hal-04013327 , version 1 (03-03-2023)

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  • HAL Id : hal-04013327 , version 1

Cite

Martial Toffano, Michael Rivard. Kinetic Resolution of Secondary Alcohols Mediated by Rabbit Gastric Lipase. Tetrahedron Letters, 1997. ⟨hal-04013327⟩
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