Kinetic Resolution of Secondary Alcohols Mediated by Rabbit Gastric Lipase
Abstract
Secondary benzylic alcohols were kinetically resolved by rabbit gastric lipase-mediated acylation with isopropenyl acetate. Among all the substrates tested, a high enantioselectivity was observed only for 1-[2-(6-methoxy)naphthyl]ethanol 3a (E>500). Allylic alcohols 14a and 15a were also efficiently resolved (E = 26 and51 respectively).