Deep Learning-Based Classification of Inherited Retinal Diseases Using Fundus Autofluorescence - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Journal of Clinical Medicine Year : 2020

Deep Learning-Based Classification of Inherited Retinal Diseases Using Fundus Autofluorescence

Abstract

Background. In recent years, deep learning has been increasingly applied to a vast array of ophthalmological diseases. Inherited retinal diseases (IRD) are rare genetic conditions with a distinctive phenotype on fundus autofluorescence imaging (FAF). Our purpose was to automatically classify different IRDs by means of FAF images using a deep learning algorithm. Methods. In this study, FAF images of patients with retinitis pigmentosa (RP), Best disease (BD), Stargardt disease (STGD), as well as a healthy comparable group were used to train a multilayer deep convolutional neural network (CNN) to differentiate FAF images between each type of IRD and normal FAF. The CNN was trained and validated with 389 FAF images. Established augmentation techniques were used. An Adam optimizer was used for training. For subsequent testing, the built classifiers were then tested with 94 untrained FAF images. Results. For the inherited retinal disease classifiers, global accuracy was 0.95. The precision-recall area under the curve (PRC-AUC) averaged 0.988 for BD, 0.999 for RP, 0.996 for STGD, and 0.989 for healthy controls. Conclusions. This study describes the use of a deep learning-based algorithm to automatically detect and classify inherited retinal disease in FAF. Hereby, the created classifiers showed excellent results. With further developments, this model may be a diagnostic tool and may give relevant information for future therapeutic approaches.
Fichier principal
Vignette du fichier
jcm-09-03303.pdf (3.26 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive

Dates and versions

hal-04054454 , version 1 (28-02-2024)

Identifiers

Cite

Alexandra Miere, Thomas Le Meur, Karen Bitton, Carlotta Pallone, Oudy Semoun, et al.. Deep Learning-Based Classification of Inherited Retinal Diseases Using Fundus Autofluorescence. Journal of Clinical Medicine, 2020, 9 (10), pp.3303. ⟨10.3390/jcm9103303⟩. ⟨hal-04054454⟩

Collections

LISSI UPEC
41 View
13 Download

Altmetric

Share

Gmail Facebook X LinkedIn More