Natural history and impact of treatment with tafamidis on major cardiovascular outcome‐free survival time in a cohort of patients with transthyretin amyloidosis - Université Paris-Est-Créteil-Val-de-Marne Accéder directement au contenu
Article Dans Une Revue European Journal of Heart Failure Année : 2021

Natural history and impact of treatment with tafamidis on major cardiovascular outcome‐free survival time in a cohort of patients with transthyretin amyloidosis

Emmanuel Itti
  • Fonction : Auteur
Violaine Planté‐bordeneuve
  • Fonction : Auteur

Résumé

Hereditary (ATTRv) and wild-type (ATTRwt) transthyretin amyloidosis are severe and fatal systemic diseases, characterised by amyloid fibrillar accumulation principally in the heart or peripheral nerves (or both). Since 2012, tafamidis has been used in France to treat patients with ATTRv with neuropathy (alone or combined with cardiomyopathy). Recently, the Phase III ATTRACT trial showed that tafamidis decreased the relative risk of mortality in ATTR amyloidosis with cardiomyopathy. The aims of this study were to assess the clinical characteristics of ATTR amyloidosis in a real-life population in comparison to the population included in the ATTRACT trial and to assess the impact of tafamidis treatment on major cardiovascular outcome (MCO)-free survival time without cardiac decompensation, heart transplant, or death.
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Dates et versions

hal-04155261 , version 1 (07-07-2023)

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Mélanie Bézard, Mounira Kharoubi, Arnault Galat, Elsa Poullot, Soulef Guendouz, et al.. Natural history and impact of treatment with tafamidis on major cardiovascular outcome‐free survival time in a cohort of patients with transthyretin amyloidosis. European Journal of Heart Failure, 2021, 23 (2), pp.264-274. ⟨10.1002/ejhf.2028⟩. ⟨hal-04155261⟩

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