Stage lighting on PAR-1: a step further in the understanding of acquired focal and segmental glomerulosclerosis
Abstract
The pathogenic mechanisms of acquired focal and segmental glomerulosclerosis are only partially known and represent a medical challenge in nephrology. The article by May et al. sheds additional light on previous data indicating the key role of the protease activated receptor 1. The new evidence is based on in vivo studies in relevant animal models and on patient biopsies and represents a significant step forward in the understanding of this pathological condition.
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