My observations in this article will be restricted to the theory of enunciation developed by Antoine Culioli (1924-2018), one of the most eminent figures in French linguistics, whose thinking has not acquired the international renown due to it – this despite the fact that English-speaking linguists, as well as those of other languages, have entered into dialogue with Harris, Chomsky, Langacker and Talmy, to name but a few. The Théorie des Opérations Prédicatives et Énonciatives (TOPE), to give it its precise name, remains unrecognized partly because its author has always refused, for reasons of scientific scruple, to issue a synthetic and didactic version which might serve as a benchmark; and partly because acceptance of the notion of enunciation is problematic, beginning with its translation into English. The questions posed in the argument of the editors of this volume, on the relationship between diagram and gesture, referring to “the hypothesis of a diagrammatology of enunciative forms in linguistics (Culioli 2018, La Mantia 2017, 2020)”, is at the heart of language theorization in TOPE. My contribution will therefore attempt to respond to the general objective of this collective publication, which is to demonstrate, insofar as I am concerned with a defined and circumscribed area of language sciences, “the heuristic role played by the concept of diagrammatic gesture in the domains of mathematical sciences and of the humanities”. My hope is that it will also enable Culioli’s compelling and original thinking to become more widely known; that it will encourage researchers to delve into it more deeply; and that it will promote interdisciplinary collaboration, which enunciation theory itself requires in accordance with its founding scientific principles.