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Journal Articles Nature Communications Year : 2021

AI-based mobile application to fight antibiotic resistance

Marco Pascucci
Guilhem Royer
Jakub Adamek
  • Function : Author
Mai Al Asmar
  • Function : Author
David Aristizabal
  • Function : Author
Laetitia Blanche
  • Function : Author
Amine Bezzarga
  • Function : Author
Guillaume Boniface-Chang
  • Function : Author
Alex Brunner
  • Function : Author
Christian Curel
  • Function : Author
Gabriel Dulac-Arnold
  • Function : Author
Rasheed Fakhri
  • Function : Author
Nada Malou
  • Function : Author
Clara Nordon
  • Function : Author
Vincent Runge
  • Function : Author
  • PersonId : 1352490
Franck Samson
Ellen Sebastian
  • Function : Author
Dena Soukieh
  • Function : Author
Jean-Philippe Vert
  • Function : Author
Christophe Ambroise
  • Function : Author
Mohammed-Amin Madoui

Abstract

Abstract Antimicrobial resistance is a major global health threat and its development is promoted by antibiotic misuse. While disk diffusion antibiotic susceptibility testing (AST, also called antibiogram) is broadly used to test for antibiotic resistance in bacterial infections, it faces strong criticism because of inter-operator variability and the complexity of interpretative reading. Automatic reading systems address these issues, but are not always adapted or available to resource-limited settings. We present an artificial intelligence (AI)-based, offline smartphone application for antibiogram analysis. The application captures images with the phone’s camera, and the user is guided throughout the analysis on the same device by a user-friendly graphical interface. An embedded expert system validates the coherence of the antibiogram data and provides interpreted results. The fully automatic measurement procedure of our application’s reading system achieves an overall agreement of 90% on susceptibility categorization against a hospital-standard automatic system and 98% against manual measurement (gold standard), with reduced inter-operator variability. The application’s performance showed that the automatic reading of antibiotic resistance testing is entirely feasible on a smartphone. Moreover our application is suited for resource-limited settings, and therefore has the potential to significantly increase patients’ access to AST worldwide.
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Origin : Publication funded by an institution

Dates and versions

hal-04283546 , version 1 (31-01-2024)

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Marco Pascucci, Guilhem Royer, Jakub Adamek, Mai Al Asmar, David Aristizabal, et al.. AI-based mobile application to fight antibiotic resistance. Nature Communications, 2021, 12 (1), pp.1173. ⟨10.1038/s41467-021-21187-3⟩. ⟨hal-04283546⟩
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