Abstract Aims Same‐day discharge (SDD) after percutaneous coronary intervention (PCI) was safe and cost‐effective in randomized and observational studies but faces limited acceptance due to concerns about early adverse events. Our aim was to evaluate early outcomes after SDD PCI in a high‐volume urban PCI center over 10 years. Methods and results From 2007 to 2016, 1,635 unselected patients had PCI at our ambulatory cardiac care unit, mainly for stable ischemic heart disease (SIHD). Among them, 1,073 (65.6%), most of whom underwent ad hoc PCI, were discharged on the same day and 562 (34.4%) were admitted, for adverse events during PCI ( n = 60) or within the next 4–6 hr ( n = 52) or chiefly due to physician preference ( n = 450). In the SDD group, radial access was used in 98.5% of patients; 36% and 15% of patients had two‐ and three‐vessel disease, respectively; and two‐vessel PCI was performed in 11% of patients. No MACCEs (death, myocardial infarction, stroke, urgent repeat PCI/CABG, and major vascular complications) occurred within 24 hr post‐discharge. Two patients were readmitted on the next day for chest pain but did not require repeat PCI. Conclusion SDD after successful PCI without complications within the next 4–6 hr is safe and feasible in most patients with SIHD. Among 1,035 SDD patients treated over 10 years, only two required readmission, and none experienced major cardiac adverse events such as death or stent thrombosis. SDD is safe for the patient and cost‐effective for the healthcare system and should be implemented more widely.