Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Journal of Infection Year : 2023

Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys

Priscilla Turelli
Yoan Duhoo
Kelvin Lau
Myriam Lamrayah
Charlène Raclot
Didier Trono
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Abstract

Highlights: • Anti-SARS-CoV-2 neutralizing antibody with ACE2 mimetic binding properties • Broad-spectrum activity against all past and current SARS-CoV-2 variants of concern • Mutations escaping mAb activity bind ACE2 poorly and are rare in circulating virus • Sterilizing protection from XBB.1.5 infection in an NHP challenge model †These authors contributed equally and ‡ authors contributed equally.
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Dates and versions

hal-04411315 , version 1 (23-01-2024)

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Craig Fenwick, Priscilla Turelli, Yoan Duhoo, Kelvin Lau, Cécile Herate, et al.. Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys. Journal of Infection, 2023, 87 (6), pp.524-537. ⟨10.1016/j.jinf.2023.10.008⟩. ⟨hal-04411315⟩
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