Broadly potent anti-SARS-CoV-2 antibody shares 93% of epitope with ACE2 and provides full protection in monkeys
Abstract
Highlights: • Anti-SARS-CoV-2 neutralizing antibody with ACE2 mimetic binding properties • Broad-spectrum activity against all past and current SARS-CoV-2 variants of concern • Mutations escaping mAb activity bind ACE2 poorly and are rare in circulating virus • Sterilizing protection from XBB.1.5 infection in an NHP challenge model †These authors contributed equally and ‡ authors contributed equally.
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