Highly Virulent Bactericidal Effects of Curcumin-Based μ-Cages Fabricated by Two-Photon Polymerization - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles ACS Applied Materials & Interfaces Year : 2020

Highly Virulent Bactericidal Effects of Curcumin-Based μ-Cages Fabricated by Two-Photon Polymerization

Davy-Louis Versace
Mehdi Belqat
  • Function : Author
Arnaud Spangenberg
  • Function : Author
Rachel Méallet-Renault
Vlasta Brezová
  • Function : Author
Jean-Pierre Malval

Abstract

A new antibacterial strategy is reported based on two-photon fabrication of three-dimensional curcumin-embedded μ-cages. Such devices were designed to entrap and kill Staphylococcus aureus bacteria upon visible light irradiation. The proposed concept mainly relies on the pivotal role of curcumin, which is sequentially used as a two-photon active free radical initiator and as a photogenerator of reactive oxygen species within the cage μ-volumes. We show that these μ-cages exhibit extremely high antimicrobial properties, leading to 95% bacteria mortality after only 10 min visible irradiation. A preconcentration mechanism of photogenerated oxygen species is proposed to account for this highly performing bactericidal effect whose virulence can be strikingly switched on by increasing the light exposure time from 5 to 10 min.
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Dates and versions

hal-04470779 , version 1 (21-02-2024)

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Davy-Louis Versace, Gabriela Moran, Mehdi Belqat, Arnaud Spangenberg, Rachel Méallet-Renault, et al.. Highly Virulent Bactericidal Effects of Curcumin-Based μ-Cages Fabricated by Two-Photon Polymerization. ACS Applied Materials & Interfaces, 2020, 12 (4), pp.5050-5057. ⟨10.1021/acsami.9b18693⟩. ⟨hal-04470779⟩
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