mcr-9 , an Inducible Gene Encoding an Acquired Phosphoethanolamine Transferase in Escherichia coli, and Its Origin - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Antimicrobial Agents and Chemotherapy Year : 2019

mcr-9 , an Inducible Gene Encoding an Acquired Phosphoethanolamine Transferase in Escherichia coli, and Its Origin

Nicolas Kieffer
  • Function : Author
Guilhem Royer
Jean-Winoc Decousser
  • Function : Author
Anne-Sophie Bourrel
  • Function : Author
Mattia Palmieri
  • Function : Author
Jose-Manuel Ortiz de la Rosa
  • Function : Author
Hervé Jacquier
  • Function : Author
Erick Denamur
  • Function : Author
Patrice Nordmann
  • Function : Author
Laurent Poirel
  • Function : Author

Abstract

The plasmid-located mcr-9 gene, encoding a putative phosphoethanolamine transferase, was identified in a colistin-resistant human fecal Escherichia coli strain belonging to a very rare phylogroup, the D-ST69-O15:H6 clone. This MCR-9 protein shares 33% to 65% identity with the other plasmid-encoded MCR-type enzymes identified (MCR-1 to -8) that have been found as sources of acquired resistance to polymyxins in Enterobacteriaceae .

Dates and versions

hal-04283204 , version 1 (13-11-2023)

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Nicolas Kieffer, Guilhem Royer, Jean-Winoc Decousser, Anne-Sophie Bourrel, Mattia Palmieri, et al.. mcr-9 , an Inducible Gene Encoding an Acquired Phosphoethanolamine Transferase in Escherichia coli, and Its Origin. Antimicrobial Agents and Chemotherapy, 2019, 63 (9), ⟨10.1128/AAC.00965-19⟩. ⟨hal-04283204⟩
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