Comparative Whole-Genome Phylogeny of Animal, Environmental, and Human Strains Confirms the Genogroup Organization and Diversity of the Stenotrophomonas maltophilia Complex - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Applied and Environmental Microbiology Year : 2020

Comparative Whole-Genome Phylogeny of Animal, Environmental, and Human Strains Confirms the Genogroup Organization and Diversity of the Stenotrophomonas maltophilia Complex

Mélanie Mercier-Darty
  • Function : Author
Guilhem Royer
Brigitte Lamy
  • Function : Author
Chadly Charron
  • Function : Author
Olivier Lemenand
  • Function : Author
Camille Gomart
  • Function : Author
Frédéric Fourreau
  • Function : Author
Jean-Yves Madec
  • Function : Author
Estelle Jumas-Bilak
  • Function : Author
Jean-Winoc Decousser

Abstract

Given its naturally large antimicrobial resistance profile, the Stenotrophomonas maltophilia complex (Smc) is a set of emerging pathogens of immunosuppressed and cystic fibrosis patients. As it is group of environmental microorganisms, this adaptation to humans is an opportunity to understand the genetic and metabolic selective mechanisms involved in this process. The previously reported genomic organization was incomplete, as data from animal strains were underrepresented. We added the missing piece of the puzzle with whole-genome sequencing of 93 strains of animal origin. Beyond describing the phylogenetic organization, we confirmed the genetic diversity of the Smc, which could not be estimated through routine phenotype- or matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF)-based laboratory tests. Animals strains seem to play a key role in the diversity of Smc and could act as a reservoir for mobile resistance genes. Some genogroups seem to be associated with particular hosts; the genetic support of this association and the role of the determinants/corresponding genes need to be explored.

Dates and versions

hal-04283225 , version 1 (13-11-2023)

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Mélanie Mercier-Darty, Guilhem Royer, Brigitte Lamy, Chadly Charron, Olivier Lemenand, et al.. Comparative Whole-Genome Phylogeny of Animal, Environmental, and Human Strains Confirms the Genogroup Organization and Diversity of the Stenotrophomonas maltophilia Complex. Applied and Environmental Microbiology, 2020, 86 (10), ⟨10.1128/AEM.02919-19⟩. ⟨hal-04283225⟩
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