In Vivo Emergence of Dual Resistance to Rifampin and Levofloxacin in Osteoarticular Cutibacterium avidum - Université Paris-Est-Créteil-Val-de-Marne Access content directly
Journal Articles Microbiology Spectrum Year : 2023

In Vivo Emergence of Dual Resistance to Rifampin and Levofloxacin in Osteoarticular Cutibacterium avidum

Scott Cunningham
  • Function : Author
Christophe Rodriguez
  • Function : Author
Paul-Louis Woerther
Christophe Menigaux
  • Function : Author
Thomas Bauer
  • Function : Author
Jean-Louis Herrmann
  • Function : Author
Martin Rottman
Anne-Laure Roux
  • Function : Author
Jean-Louis Gaillard
  • Function : Author
Robin Patel
Faten El Sayed

Abstract

In this study, we report for the first time the in vivo emergence of dual resistance to levofloxacin and rifampin in C. avidum isolated from a patient who received both antibiotics orally in the setting of a salvage debridement and implant retention of an ODRI. Aside from the molecular insights reported here, this study highlights potential limitations of the combination of oral rifampin and levofloxacin in patients undergoing these surgical procedures and the potential need to evaluate specific optimal therapy for emerging ODRI pathogens.

Dates and versions

hal-04297809 , version 1 (21-11-2023)

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Scott Cunningham, Christophe Rodriguez, Paul-Louis Woerther, Christophe Menigaux, Thomas Bauer, et al.. In Vivo Emergence of Dual Resistance to Rifampin and Levofloxacin in Osteoarticular Cutibacterium avidum. Microbiology Spectrum, 2023, 11 (4), ⟨10.1128/spectrum.03687-22⟩. ⟨hal-04297809⟩
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